World-class protein optimisation to solve the toughest functional challenges.
Services
Engineered for Function. Built for Impact.
We offer a range of services designed to empower your protein-based projects:
Expression levels and stability improvements;
Protein binding assessment and improvement;
Antibody improvements;
Binding specificity and affinity assessment and improvement;
PK/PD analyses, including aggregation propensity prediction and improvement;
Small molecule drug screening in silico;
Structure-function analyses and predictions;
Book a free call to discuss your project.
Book a 1 hour consulting session with a highly experienced protein engineer who can give fast and effective support.
Book an Alphafold modelling session with one of our experts to discuss the structure of your protein and suggest improvements.
About
PTNG Scientific's mission is to provide scientifically accurate, cutting-edge support and advice in protein engineering to businesses and universities.
Our Clients
Our Partners
Thank you for your outstanding service and excellent reports, which were comprehensive and clear, making it easy for us to understand and act upon. PTNG Consulting used advanced computational approaches for binding site prediction of our target angiotensin-converting enzyme, and ranked the potential binding sites for virtual screening. A virtual screen campaign was carried out using the ligand discovery database ZINC 20. By combining chemical diversity with the highest accuracy ranking, a set of 100 compounds was selected, which provided a good sampling of diverse physio-chemical properties and served as an excellent starting point to identify novel high affinity molecules. The consultants working on the project are world-class scientists who are inspired to learn the mechanisms of pharmacology and biology at the molecular level to make the most impact. We have enjoyed working with the PTNG team enormously and look forward to further interaction on this project.
—Ed Sturrock
Director, AngioDesign and Professor of Chemical & Systems Biology, University of Cape Town
PTNG Consulting has played an instrumental role in ProteinLogic's recent fundraising efforts. Their team has provided efficient and professional project management capabilities, and has helped us to successfully assemble an ambitious international project spanning several continents. They have, additionally, provided immensely valuable grant writing expertise and strategic advice that has greatly facilitated our project development activities. We have enjoyed working with them, highly recommend them, and look forward to engaging with them on future projects.
—Adrian Woolfson
Founder and Non-Executive Director of ProteinLogic
We enjoyed a successful and constructive experience in retaining PTNG for our GGF PharmaDesign project. After 5 years of basic research for our DNA visualization algorithm we developed a software application involving reversal of the GGF algorithm to design proteins for biologic pharmaceuticals. We wanted a testing protocol to gauge the efficacy of our software to produce viable pharmacophore peptide candidates. This project was a complex, challenging assignment but PTNG managed all these challenges seamlessly and professionally. They were able to analyze our many software modules because key members of the PTNG project team were not only expert microbiologists, but conversant in both Mathematica and Python. We were particularly impressed with their approach to prepare a feasibility study that included a testing protocol for our novel software which was without precedent and so required locating hard to find datasets that were critical in demonstrating utility of our software. They also provided guidance on navigating the scope of the project to minimize costs and maintain focus. Overall PTNG have been reliable, supportive and friendly in providing highly specialized expertise and advice.
—C.C. Hagan
Chairman & Executive GM, Biophysical Cancer Research Foundation Ltd, GGF Global Genomics Pty Ltd
